Tara Crawfod

PREP Scholar, Department of Biology

I am a first year PREP scholar in the department of Biology. My laboratory focuses on Osteogenesis Imperfecta, also known as brittle bone disease. Osteogenesis Imperfecta is a genetic disorder and causes both bone and muscle weakness. My research uses a mouse model to investigate bone and muscle strength in mice pups by inhibiting myostatin in pregnant mice. Myostatin is a regulator of muscle growth and prevents muscles from getting too big, so by inhibiting this in the mice moms during pregnancy, her muscles get bigger. The hypothesis is that this will help the mice pups with Osteogenesis Imperfecta have stronger muscles and bones

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